Macrophage Subsets in Human Atherosclerosis

Macrophage subsets in human atherosclerosis.

Monocyte subsets in atherosclerosis.

Endothelial dysfunction and chronic inflammation of the arterial wall continuously drive the development of atherosclerotic lesions. Monocytes, as cells of the innate immunity, are particularly involved in this process. In the last decade, heterogeneity of circulating monocytes has widely been acknowledged, and a recent consensus nomenclature subdivides classical, intermediate and nonclassical ...

Expression of interleukin-6 receptor subunits in human macrophage subsets.

B Cell Subsets in Atherosclerosis

Atherosclerosis, the underlying cause of heart attacks and strokes, is a chronic inflammatory disease of the artery wall. Immune cells, including lymphocytes modulate atherosclerotic lesion development through interconnected mechanisms. Elegant studies over the past decades have begun to unravel a role for B cells in atherosclerosis. Recent findings provide evidence that B cell effects on ather...

Macrophage functions in atherosclerosis.

A therosclerosis is a chronic inflammatory disease of the arterial wall instigated by the excessive accumulation of lipoproteins; monocyte recruitment and their differentiation into macrophages in the subendothelial space. Repeated failure of innate immune responses to clear subintimal low-density lipoprotein (LDL), results in the deposition of lipid-laden macrophages or foam cells. Foam cells ...